NATURAL PRODUCT AND DRUG DISCOVERY

理工学部 - 物質生命理工学科

SML6740E

コース情報

担当教員: LUHATA Lokadi

単位数: 2

年度: 2024

学期: 秋学期

曜限: 火4

形式: 対面授業

レベル: 300

アクティブラーニング: あり

他学部履修: 不可

評価方法

出席状況

20%

リアクションペーパー

30%

レポート

50%

詳細情報

概要

This course provides the basics concepts in natural products chemistry. The book written by Paul Dewick will be used a textbook. Additional topics will be selected in others books. Students will learn technical knowledge related to the drug development process from natural products.

目標

To understand the use of herbal and natural medicines in the human history. To understand the technics used in the isolation and elucidation of active secondary metabolites. To identify the lead compound for drug development.

授業外の学習

The students are expected to read several chapters of the book and solve some problems before and after the class.

所要時間: 190 min

スケジュール

Chapter 1: History of Drug Discovery
Chapter 2: Natural Products Sources
Chapter 3: Secondary Metabolism: The Building Blocks and Construction Mechanisms
Chapter 4: Extraction and Separation of Natural Products
Chapter 5: Structure Elucidation
Chapter 6: Strategies for Identification of Novel Therapeutic Leads from Natural Products
Chapter 7: Bioassays for Activity: in vitro and in vivo Assays
Chapter 8: Natural Products in Cancer Chemoprevention and Chemotherapy
Chapter 9: Isolation of Bioactive Natural Products from Odontonema strictum
Chapter 10: Marine Natural Products as Leads to Develop New Drugs and Insecticides
Chapter 11: Drug Development Process
Chapter 12: Structure–Activity Relationships of Some Biologically Active Natural Products
Chapter 13: Standardization and Biological Activity
Chapter 14: Recent Trends in the Use of Natural Products and their Derivatives as Potential Pharmaceutical Agents

教科書

Biologically Active Natural Products. CRC Press.

著者: Cutler, Stephen J. Cutler, Horace G.

出版社: 2000

参考書

書籍情報はありません。